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Clouser was a member of NIN from 1994-2000 and was part of the live band on the [[Self Destruct]] and [[Fragility]] Tours, as well as collaborating with [[Trent Reznor]] in the studio on various projects; one such collaboration being the [[Natural Born Killers Soundtrack|Natural Born Killers]] Soundtrack on which he aided in recording and producing a new version of ''[[Something I Can Never Have]]''. His work can also be heard on releases such as ''[[Further Down the Spiral]]'' and ''[[Things Falling Apart]]''.
Charlie Clouser has also done remixes for various bands, including: White Zombie, [[Marilyn Manson]], Rammstein, Prong, Killing Joke, Type O Negative, Zilch, Schwein, Collide, [[12 Rounds]], Foetus, Meat Beat Manifesto and Esthero.
He has also worked as a composer, scoring the films Saw (2004), Saw II (2005), Saw III (2006) and the TV series Las Vegas; he is currently the composer for the series NUMB3RS.