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Cortini was born in the Italian city of Bologna and raised in Forli. Sometime around 1998, Cortini moved to the United States to study guitar at the Musicians Institute; after , where he met Swedish guitarist Pelle Hillström. After graduating he began focusing on keyboards and synths. While briefly teaching at the Musicians Institute, he saw an ad for open auditions for Nine Inch Nails; after impressing [[Trent Reznor]] in his audition, he was brought on board to form the live band for the 2005 [[Live: With Teeth]] tour and has been a member of the band ever since.

Cortini is also the frontman of Los Angeles-area band [[modwheelmood]], which he leads with former-Abandoned Pools guitarist Pelle Hillstrom; the . The band is signed to fellow NIN bandmate [[Aaron North]] and Travis Keller's record label, Buddyhead. Prior to forming modwheelmood, Cortini acted as touring guitarist for The Mayfield Four. Cortini currently resides in the Los Angeles area with his dog and three cats.